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KMID : 0923620150150040186
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Immune Network
2015 Volume.15 No. 4 p.186 ~ p.190
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Cytomegalovirus Infection and Memory T Cell Inflation
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:Kim Ji-Hye
:Kim A-Reum/:Shin Eui-Cheol
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Abstract
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Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8+ T cells, termed ’memory inflation’. The expanded CMV-specific CD8+ T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8+ T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.
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KEYWORD
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Cytomegalovirus, T cells, Senescent T cells, Memory inflation, Immunosenescence
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